![]() ![]() Patients could be infected by either a single pathogen or a mixture of Gram-negative and Gram-positive bacteria. The pathogens of acute cholangitis ascend from the intestinal tract, mainly Gram-negative bacilli and Gram-positive cocci. Timely biliary drainage and the use of appropriate antibiotics are the keys to improving the prognosis. Acute cholangitis has a high mortality rate up to 10% even after aggressive treatment. It is commonly related to biliary stones and biliary tract tumors it can cause septic shock and multiple organ dysfunction in severe cases. There were no apparent differences between Gram-negative and Gram-positive bacterial infections.Īcute cholangitis is an inflammation of the bile duct caused by biliary tract bacterial infection due to biliary tract obstruction. In acute cholangitis, mixed infection with Gram-negative and Gram-positive bacteria was more severe and was associated with a higher risk of death. The proportion of Grade III patients and the APACHE II and SOFA scores of the mixed Gram-negative and positive group were the highest (p 0.05). Among the 313 patients (73.8%) with bacterial growth, 155 patients had only Gram-negative bacteria cultured (49.5%), 48 patients had only Gram-positive bacteria cultured (15.3%), and 110 patients had both Gram-negative and Gram-positive bacteria cultured (35.1%). ResultsĪ total of 424 patients were included, and no bacterial growth developed in 111 patients (26.2%). The severity of illness, organ dysfunction, and prognosis of the groups were analyzed and compared comprehensively. Patients who met the selection criteria according to blood culture and bile culture results of different pathogenic bacterial were divided into groups. MethodsĪ retrospective observational study was performed. To investigate the difference in the severity of illness, organ dysfunction, and prognosis of acute cholangitis due to different pathogenic bacterial infection types. ![]()
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